trigonelline hydrochloride
trigonelline hydrochloride
CAS: 6138-41-6
Molecular Formula: C7H8ClNO2
trigonelline hydrochloride - Names and Identifiers
| Name | trigonelline hydrochloride |
| Synonyms | TRIGONELLINE HCL EINECS 228-119-5 TIMTEC-BB SBB000182 TRIGONELLIN HYDROCHLORIDE trigonelline hydrochloride TRIGONELLINE HYDROCHLORIDE 3-carboxy-1-methylpyridinium 3-carboxy-1-methylpyridinium chloride 3-Carboxy-N-methylpyridinium chloride N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE 1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE |
| CAS | 6138-41-6 |
| EINECS | 228-119-5 |
| InChI | InChI=1/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H |
trigonelline hydrochloride - Physico-chemical Properties
| Molecular Formula | C7H8ClNO2 |
| Molar Mass | 173.6 |
| Melting Point | ~260°C (dec.) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White solid |
| Color | White to Off-White |
| Merck | 14,9694 |
| BRN | 3734169 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00077250 |
| Physical and Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from fenugreek. |
| In vitro study | It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 . |
| In vivo study | Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats. |
trigonelline hydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29333990 |
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Product Name: Trigonelline Chloride Visit Supplier Webpage Request for quotationCAS: 6138-41-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Trigonelline Hydrochloride Visit Supplier Webpage Request for quotationCAS: 6138-41-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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